Blood pressure responsiveness to resistance training in the hypertensive older adult: a randomized controlled study.

Different lifestyle changes have been employed to improve clinical hypertension. However, there is scarce evidence on the blood pressure responsiveness to resistance training (RT) in hypertensive older adults. Consequently, little is known about some participants clinically reducing blood pressure and others not. Thus, we investigate the effects and responsiveness of RT on blood pressure in hypertensive older adults. We secondarily evaluated the biochemical risk factors for cardiovascular disease and functional performance. Older participants with hypertension were randomly assigned into RT (n = 27) and control group (n = 25). Blood pressure, functional performance (timed up and go, handgrip strength, biceps curl and sit-to-stand), fasting glucose, and lipid profiles were evaluated preintervention and postintervention. The statistic was performed in a single-blind manner, the statistician did not know who was the control and RT. RT was effective in reducing systolic blood pressure (SBP) (pre 135.7 ±â€…14.7; post 124.7 ±â€…11.0; P  < 0.001) and the responses to RT stimuli varied noticeably between hypertensive older adults after 12 weeks. For example, 13 and 1 responders displayed a minimal clinical important difference for SBP attenuation (10.9 mmHg) in the RT and control groups, respectively. RT improved the functional performance of older people with hypertension, while no differences were found in biochemical parameters (triglycerides, HDL, LDL, fasting glucose) after 12 weeks. In conclusion, responses to RT stimuli varied noticeably between hypertensive individuals and RT was effective in reducing SBP.

Association between ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M268T) polymorphisms and performance phenotypes in Brazilian swimmers.

BACKGROUND: The influence of genetic polymorphisms on athletic performance has been widely explored. This study investigated the interactions between the polymorphisms ACTN3 (R577X), ACE (I/D), BDKRB2 (-9/+9), and AGT (M/T) and their association with endurance and strength phenotypes in Brazilian swimmers. METHODS: 123 athletes (aged 20-30 years) and 718 controls participated in the study. The athletes were divided into elite and sub-elite (N = 19 and 104, respectively) and strength and endurance experts (N = 98 and 25, respectively). Hardy-Weinberg equilibrium was observed in all groups. RESULTS: Considering the ACE polymorphism, it was observed a higher frequency of the DD genotype than expected in the strength experts of the elite group, whereas the strength experts sub-elite athletes had a higher frequency of the ID genotype (χ2 = 8.17; p = 0.01). Subjects with XX genotypes of ACTN3 are more likely to belong to the athlete group when compared to the control group (OR = 1.79, p = 0.04). The DD homozygotes of the ACE are more likely to belong to the elite group with strength phenotypes than the group of sub-elite (OR = 7.96, p = 0.01) and elite strength experts compared to elite endurance (OR = 18.0, p = 0.03). However, no significant differences were observed in the allelic distribution of the polymorphisms evaluated when comparing Elite, sub-elite athletes and controls. CONCLUSION: ACE and ACTN3 allele frequencies should be considered with regard to performance influencing factors in Brazilian swimmers.

Cognition in soccer and futsal: evidence of validity of a 4-instrument protocol to assess executive functioning among women athletes.

Evidence suggests that success in sports, especially soccer and futsal are linked to higher levels of executive functioning. Still, the literature does not present a homogeneous set of instruments to measure executive functions, which leads to large variability in results. In this paper, we assembled four already recognised measures to propose a valid 4-instrument protocol to assess executive functions among soccer and futsal athletes. We conducted two studies to validate the proposed protocol. We addressed known-groups validity and latent structure in Study 1 for data collected on 105 female soccer and futsal athletes from elite and lower-division clubs. Findings pointed to partial validity of the protocol - with working memory and inhibition showing the best results. For Study 2, we used performance data from 51 elite female soccer players collected throughout a season of the first division league to assess predictive validity. Our protocol was able to partially replicate previous findings and added new insights on how working memory, processing speed and higher-level executive functions might play different roles for goalscoring and assist-making skills. Specifically, study 1 did not find a significant difference between elite and lower-division athletes in higher-order executive functions as in previous studies, but it did find on visual working memory and inhibitory control which weights towards higher demands of core executive functions. On the other hand, study 2 yielded significant results for processing speed and visual working memory to predict assists among elite soccer players, but not inhibitory control as previous findings suggested. Regardless, the proposed 4-instrument protocol showed adequate criterion and structural validity in both studies.

Características psicométricas da versão brasileira do Sport Emotion Questionnaire (SEQ-BR) / Características psicométricas de la versión brasileña del Sport Emotion Questionnaire (SEQ-BR) / Psychometric characteristics of the Brazilian version of the Sport Emotion Questionnaire (SEQ-BR)

En este trabajo presentamos una versión traducida y adaptada del Sport Emotion Questionnaire (SEQ) en portugués brasileño, además de explorar sus características psicométricas. En el Estudio 1 se elaboró la versión brasileña del SEQ (SEQ-BR) de acuerdo con las directrices del proceso de adaptación transcultural, se evaluó la validez de contenido y el acuerdo entre evaluadores. La concordancia entre los evaluadores fue casi excelente (0.77 £ Kappa £ 0.89) y el instrumento se consideró válido desde el punto de vista de su contenido en cuanto a claridad (CVCt = 0.91) y pertinencia (CVCt = 0.93). En el Estudio 2, 895 atletas brasileños de diferentes deportes respondieron al SEQ-BR durante competiciones nacionales e internacionales. Se realizaron análisis factoriales para explorar y confirmar la estructura factorial del SEQ-BR. La estructura con cinco factores presentó un ajuste satisfactorio [χ2 (199) = 395.59; χ2/gl = 1.99; CFI = 0.98; TLI = 0.98; GFI = 0.98; RMSEA = 0.033], además de invarianza factorial entre grupos y consistencia interna adecuada en todos los factores (0.78 £ ω £ 0.85). Teniendo en cuenta lo anterior, el SEQ-BR presenta adecuación en cuanto a la validación del contenido y características psicométricas satisfactorias, proporcionando un instrumento estable, consistente y fiable para medir las emociones precompetitivas en atletas brasileños. (AU)

Neste trabalho apresentamos uma versão traduzida e adaptada doSport Emotion Questionnaire(SEQ) para o Português brasileiro, e exploramossuas características psicométricas. No Estudo 1 foi produzida a versão brasileira do SEQ (SEQ-BR)de acordo com as diretrizes para o processo de adaptação transcultural, eavaliadas a validade de conteúdo e a concordância entre os juízes. O julgamento quanto a concordância entre os juízes foi quase excelente (0.77£Kappa£0.89) e o instrumento foi considerado válido do ponto de vista do seu conteúdo quanto a clareza (CVCt= 0.91) e pertinência (CVCt= 0.93). No Estudo 2, 895 atletas brasileiros de diferentes modalidades esportivas responderam o SEQ-BR durante competições nacionais e internacionais. As análises fatoriais foram realizadas para explorar e confirmar a estrutura fatorial do SEQ-BR. Aestrutura com cinco fatores apresentou um ajuste satisfatório [χ2(199) = 395.59; χ2/gl = 1.99; CFI = 0.98;TLI = 0.98;GFI = 0.98;RMSEA = 0.033], além de invariância fatorial entre grupos e consistência interna adequada em todos os fatores (0.78£ω£0.85). Diante do exposto, o SEQ-BR apresenta adequação quanto à validação do conteúdo e características psicométricas satisfatórias, fornecendo um instrumento estável, consistente e confiável para mensurar emoções pré-competitivas em atletas brasileiros. (AU)

Here we present an adapted version oftheSport Emotion Questionnaire (SEQ)translated to Brazilian Portuguese, and exploreits psychometric characteristics. In Study 1, the Brazilian version of the SEQ (SEQ-BR) was produced according to the guidelines for the cross-cultural adaptation process, and the content validity and inter-rater agreement were evaluated. The agreement was almost excellent between judges (0.77£Kappa£0.89),and the instrument was considered valid from thecontent viewpoint, regarding clarity (CVCt= 0.91) and relevance (CVCt= 0.93). In Study 2, 895 Brazilian athletes from different types of sports answered the SEQ-BR during national and international competitions. Factor analysis were performed to exploreand confirm the factor structure of the SEQ-BR.The structure composed offive factors [χ2(199) = 395.59;χ2/df = 1.99; CFI = 0.98;TLI = 0.98;GFI = 0.98;RMSEA = 0.033], in addition to factorial invariance between groups and adequate internal consistency in all factors (0,78£ω£0,85). The SEQ-BR presents adequacy as to content validity,and satisfactory psychometric characteristics, providing a stable, consistent, and reliable instrument tomeasure pre-competitive emotions in Brazilian athletes. (AU)

Interesses culturais do lazer: práticas versus desejo de vivências de servidores públicos federais aposentados antes da pandemia / Cultural interests of leisure: practices versus desire for the experiences of retired federal public servers before the pandemic

O lazer é uma das alternativas almejadas pelas pessoas para o momento da velhice e da aposentadoria. O objetivo deste estudo foi identificar e comparar os interesses culturais do lazer mais praticados e os que os servidores públicos federais aposentados do Fundo Nacional de Desenvolvimento da Educação mais gostavam de praticar antes da pandemia. Identificou-se os mais praticados, em ordem decrescente: virtuais, esportivos, intelectuais, turísticos, manuais, sociais e artísticos, e os que preferiam: turísticos, sociais, esportivos, artísticos, intelectuais, manuais e virtuais. Assim, verificou-se que as atividades praticadas não condiziam com aquelas às quais desejariam se dedicar, dado esse que nos indica a necessidade de se trabalhar com a educação para e pelo lazer ao longo de toda a vida para que o lazer seja melhor vivenciado e usufruído quando chegada a aposentadoria.

Leisure is one of the alternatives desired by people for the time of old age and retirement. The objective of this study was to identify and compare the cultural interests of leisure most practiced and those that retired federal civil servants from the National Education Development Fund most liked to practice before the pandemic. The most practiced were identified, in descending order: virtual, sporty, intellectual, tourist, manual, social and artistic, and those who prefered: tourist, social, sports, artistic, intellectual, manual and virtual. Thus, it was found that the activities performed are not consistent with those they would like to engage in, which indicates the need to work with education for and through leisure throughout life so that leisure is better experienced and enjoyed when retirement comes.

Praying for a Miracle: Negative or Positive Impacts on Health Care?

The belief in miracle, as a modality of spiritual/religious coping (SRC) strategy in the face of stress and psychic suffering, has been discussed in psychological literature with regard to its positive or negative role on the health and well-being of patients and family members. In contemporary times, where pseudo-conflicts between religion and science should have been long overcome, there is still some tendency of interpreting belief in miracle - as the possibility of a cure granted by divine intervention, modifying the normal course of events in a bleak medical diagnosis - as having unhealthy impacts in the care and treatment of health. This position seeks to find a base in the three characteristics of hoping in a miracle, frequently pointed out by psychological literature: (a) it would imply a negation of reality instead of its confrontation; (b) it would be a coping strategy focused on emotion instead of the problem; (c) it would imply seeking to modify the supposed desire of God by extra-natural facts. In this study, we shall critically discuss this position and the dangers of its crystallization by the use of SRC scales in which the act of praying for a miracle is previously classified as a negative strategy. We revisit some tendencies in psychological literature about the subject, taking into consideration the various facets of miracle, sociocultural facts, elements of idiographic nature, and their profound outcomes in the lives of people especially in health contexts. We illustrate the dangers of a hasty generalization of the results of nomothetic studies about the role of belief in miracle with two examples of research in the Brazilian context: one carried out with pregnant women with fetal malformation and the other with family members caring for children and adolescents with cancer under chemotherapeutic treatment. In both studies, the results do not confirm the predominance of the negative aspects associated with the act of praying for a miracle, which we discuss and analyze in light of the phenomenological perspective. In this perspective, "pray for a miracle", as experienced by patients and caregivers, can be recognized as an act of openness to life (instead of isolation in a bleak perspective), bolstering hope, and the resignification of reality in the psyche.

Metabolic and hormonal responses to chronic blood-flow restricted resistance training in chronic kidney disease: a randomized trial.

Maintenance of glycemic and lipemic homeostasis can limit the progression of diabetic kidney disease. Resistance training (RT) is effective in controlling glycemia and lipemia in kidney disease; however, the effect of RT with blood flow restriction (RT+BFR) on these metabolic factors has not been investigated. We aimed to verify if chronic (6 months) RT and RT+BFR performed by patients with stage-2 chronic kidney disease (CKD) improves their glycemic homeostasis and immunometabolic profiles. Patients with CKD under conservative treatment (n = 105 (33 females)) from both sexes were randomized into control (n = 35 (11 females); age 57.6 ± 5.2 years), RT (n = 35 (12 females); age 58.0 ± 6.2 years), and RT+BFR (n = 35 (10 females); 58.0 ± 6.4 years) groups. Chronic RT or RT+BFR (6 months) was performed 3 times per week on non-consecutive days with training loading adjusted every 2 months, RT 50%-60%-70% of 1RM, and RT+BFR 30%-40%+50% of 1RM and fixed repetition number. Renal function was estimated with the glomerular filtration rate and serum albumin level. Metabolic, hormonal, and inflammatory assessments were analyzed from blood samples. Six months of RT and RT+BFR were similarly effective in improving glucose homeostasis and hormone mediators of glucose uptake (e.g., irisin, adiponectin, and sirtuin-1), decreasing pro-inflammatory and fibrotic proteins, and attenuating the progression of estimated glomerular filtration rate. Thus, RT+BFR can be considered an additional exercise modality to be included in the treatment of patients with stage 2 chronic kidney disease. Trial registration number: U1111-1237-8231. URL: http://www.ensaiosclinicos.gov.br/rg/RBR-3gpg5w/, no. RBR-3gpg5w. Novelty: Glycemic regulation induced by resistance training prevents the progression of CKD. Chronic RT and RT+BFR promote similar changes in glycemic regulation. RT and RT+BFR can be considered as non-pharmacological tools for the treatment of CKD.

Interaction Between ACTN3 (R577X), ACE (I/D), and BDKRB2 (-9/+9) Polymorphisms and Endurance Phenotypes in Brazilian Long-Distance Swimmers.

ABSTRACT: Neto, SLdA, Herrera, JJB, Rosa, TS, de Almeida, SS, Silva, GCB, Ferreira, CES, dos Santos, MAP, Silvino, VO, de Melo, GF. Interaction between ACTN3 (R577X), ACE (I/D), and BDKRB2 (-9/+9) polymorphisms and endurance phenotypes in Brazilian long-distance swimmers. J Strength Cond Res 36(6): 1591-1595, 2022-This study investigated the interactions between the polymorphisms ACTN3 (R577X), ACE (I/D), and BDKRB2 (-9/+9) and their association with endurance phenotypes in Brazilian long-distance swimmers. Twenty-six volunteers (aged 18-30 years) were divided into 2 groups as follows: 19 subelite athletes formed the pool swimming experts (PSE: 400-1500 m) group and 7 elite athletes the open water swimming experts (OWSE: 5-25 km) group. ACTN3 (R577X), ACE (I/D), and BDKRB2 (-9/+9) polymorphisms were genotyped through polymerase chain reaction. A nonathletes control (CON) group derived from studies with the Brazilian population was created. Hardy-Weinberg equilibrium (X2) was observed in all groups. The total genotype score (TGS) associated with endurance phenotypes was used in this study. A significance level was established at p ≤ 0.05. PSE and CON groups had very similar genotyping distribution. The OWSE group had a greater frequency for the genotypes XX (57.1%), ID (57.1%), and the alleles X (71.4%) and I (57.2%) than CON and PSE groups (XX = 21.1 and 21.1%; ID = 47.1 and 52.6% [p > 0.05]; X = 44.0 and 42.1%; I = 45.3 and 42.1%, respectively). Considering BDKRB2, OWSE and PSE groups had a greater frequency of +9/+9 than the CON group (42.9% and 31.6 vs. 27.5%, respectively). Although the expected genotypic distribution was not verified among athletes, the TGS revealed small supremacy of 3-5 typical alleles in the OWSE group (54.8 ± 26.7%) compared with the PSE group (41.2 ± 17.8%) (p = 0.072; confidence interval = 95%; effect size = 0.95). The OWSE group seem to have benefited from the best genotype profile verified for ACTN3 and ACE. However, the results of this work should be approached with caution because of the small number of athletes and polymorphisms assessed.

Evidence of Validity and Perspectives for Resilience Scales in Sport / Evidências de Validade e Perspectivas para Escalas de Resiliência no Esporte

Abstract The aim of this review was to identify the scales used to measure resilience in athletes and to assess their psychometric and semantic adaptations for the sporting context. An electronic search was conducted in six databases, for 2008-2019, and 43 articles were selected. The results showed 11 scales applied to evaluate resilience in athletes. In the semantic field, 11 factors were identified, conceptually different, that define the property of the psychological system for sports resilience. This study concluded that scales identified in literature to assess athletes' resilience have been used indiscriminately. Only five had their psychometric properties evaluated for the sports context. Therefore, sport psychology lacks a sport-specific measure for resilience.

Resumo O objetivo desta revisão foi identificar as escalas utilizadas para avaliar a resiliência em atletas bem como as adaptações psicométricas e semânticas para o contexto esportivo. Uma busca eletrônica foi conduzida em seis bases de dados, 2008-2019. Foram selecionados 43 artigos. Os resultados mostraram 11 escalas aplicadas para avaliar a resiliência em atletas. No campo semântico, foram identificados 11 fatores, conceitualmente distintos, que definem a propriedade do sistema psicológico para a resiliência esportiva. Este estudo concluiu que as escalas identificadas na literatura para avaliar a resiliência de atletas têm sido usadas de forma indiscriminada. Apenas cinco tiveram suas propriedades psicométricas avaliadas para o contexto esportivo. Portanto, a psicologia do esporte carece de uma medida específica do esporte para resiliência.

Sports participation among Brazilian adolescents and children: systematic review / Participação esportiva entre adolescentes e crianças brasileiras: revisão sistemática

Abstract The aim of this study is to describe the prevalence of sports participation in Brazilian children and adolescents through a systematic literature review. A search was carried out in the following electronic databases: MEDLINE, WEB OF SCIENCE, BIREME, SCIELO, and SCOPUS for manuscripts published until 2020, combining the keywords: "children", "adolescents", "prevalence", and "sports participation", in Portuguese and English. Twenty-six articles published between 2003 and 2020 were included in the review, with the aim of estimating the prevalence of participation in organized sports in Brazilian children and adolescents. Considering the regions where the studies were carried out, the majority were developed in the south (57.7%; n=15), followed by the southeast (19.2%; n=05), and northeast (15.4%; n=04), in addition to 7.7% (n=02) in all regions of the country. The data showed prevalence of sports participation ranging from 15.0% to 73.2% (mean of 44.8%) among children and adolescents, being higher in males (63.1%). From the results found, the need to develop public policies is evident, in order to favor adherence and maintenance of young people to sports practice, especially among those of the female sex.

Resumo O objetivo deste estudo foi descrever a prevalência de participação esportiva em crianças e adolescentes brasileiros por meio de uma revisão sistemática de literatura. A busca foi realizada nas seguintes bases de dados eletrônicas: MEDLINE, WEB OF SCIENCE, BIREME, SCIELO e SCOPUS de manuscritos publicados até o ano de 2020, por meio da combinação das palavras-chave: "crianças", "adolescentes", "prevalência" e "participação esportiva", em português e inglês. Foram incluídos na revisão 26 artigos publicados no período de 2003 a 2020, com objetivo de estimar a prevalência de crianças e adolescentes brasileiros acerca da participação em esportes organizados. Quanto a região de realização do estudo, a maioria foi desenvolvido no sul (57.7%; n=15), seguido do sudeste (19.2%; n=05) e nordeste (15.4; n=04), além de 7.7% (n=02) em todas as regiões do país. Os dados mostraram prevalências de participação esportiva que variaram entre 15.0% a 73.2% (média de 44.8%) entre crianças e adolescentes, sendo superior no sexo masculino (63.1%). A partir dos resultados encontrados evidencia-se a necessidade do desenvolvimento de políticas públicas para favorecera aderência e manutenção de jovens para a prática esportiva, principalmente entre aqueles do sexo feminino.

Benefits of combined interventions for cognitive enhancement in older adults / Benefícios de intervenções combinadas para aprimoramento cognitivo em idosos

Objective: To investigate the effects of different combined interventions (Stimullus, MEMO, physical activity, and psychoeducation) on the cognitive performance of older adults. Methods: This is a quasi-experimental study with pre- and post-intervention. Thirty-four older adults underwent different combined interventions for a period of 48 weeks and were evaluated at three different points (pre-intervention; post-cognitive intervention; post-physical activity or psychoeducation intervention). Cognitive domains (verbal episodic memory, executive function, general cognitive performance) and depressive symptoms were evaluated. Results: Postintervention gains in global, attentional, and mnemonic cognition were observed, as well as a reduction in depressive symptoms. The MEMO intervention + physical activity or psychoeducation resulted in greater cognitive gains, while Stimullus + psychoeducation showed benefits only in evocation and the free learning index, while Stimullus + physical activity resulted in improvement in the investigated variables. Conclusion: The results of these combined interventions appear promising for healthy older adults and the impact of these interventions should be discussed with individual older patients and evaluated more broadly in the context of public health.

Objetivo: Investigar os efeitos de diferentes intervenções combinadas (Stimullus, MEMO, física e psicoeducacional) no desempenho cognitivo de idosos. Metodologia: Trata-se de um estudo quase experimental com pré e pós-intervenção. Trinta e quatro idosos foram submetidos a diferentes intervenções combinadas pelo período de 48 semanas e avaliados em três tempos diferentes (pré-intervenção; pós-intervenção cognitiva; pós-intervenção física ou psicoeducacional), nos quais foram analisados domínios cognitivos (memória episódica verbal, funções executivas, desempenho cognitivo geral) e sintomas depressivos. Resultados: Após as intervenções, observaram-se ganhos na cognição global, atencional e mnemônica, bem como redução dos sintomas depressivos. A intervenção MEMO (física ou psicoeducacional) resultou em maiores ganhos cognitivos, enquanto Stimullus + psicoeducacional demonstrou benefícios apenas no índice de evocação e aprendizagem livre, e Stimullus + atividades físicas não apresentou melhora em nenhuma das variáveis investigadas. Conclusão: Os achados positivos dessas intervenções combinadas parecem promissores no contexto de idosos saudáveis, e o impacto dessas intervenções deve ser discutido em relação às especificidades de cada indivíduo idoso e avaliado mais amplamente no contexto de saúde pública.

Are Resistance Training-Induced BDNF in Hemodialysis Patients Associated with Depressive Symptoms, Quality of Life, Antioxidant Capacity, and Muscle Strength? An Insight for the Muscle-Brain-Renal Axis.

BACKGROUND: Hemodialysis patients are suffering from depressive symptoms. Brain-derived neurotrophic factor (BDNF) levels are negatively associated with depressive symptoms and decrease during a single hemodialysis session. Resistance training (RT) might be an additional non-pharmacological tool to increase BDNF and promote mental health. METHODS: Two randomized groups of hemodialysis patients: control (CTL, n = 76/F36; 66.33 ± 3.88 years) and RT (n = 81/F35; 67.27 ± 3.24 years). RT completed six months of training thrice a week under the supervision of strength and conditioning professional immediately before the dialysis session. Training loads were adjusted using the OMNI rating of perceived exertion. The total antioxidant capacity (TROLOX), glutathione (GSH), thiobarbituric acid reactive substance (TBARS), and BDNF levels were analyzed in serum samples. Quality of life (assessed through Medical Outcomes-SF36), and Beck Depression Inventory was applied. RESULTS: RT improved handgrip strength (21.17 ± 4.38 vs. 27.17 ± 4.34; p = 0.001) but not for CTL (20.09 ± 5.19 vs. 19.75 ± 5.54; p = 0.001). Post-training, RT group had higher values as compared to CTL related to TROLOX (RT,680.8 ± 225.2 vs. CTL,589.5 ± 195.9; p = 0.001) and GSH (RT, 9.33 ± 2.09 vs. CTL,5.00 ± 2.96; p = 0.001). RT group had lower values of TBARS as compared to CTL at post-training (RT, 11.06 ± 2.95 vs. CTL, 13.66 ± 2.62; p = 0.001). BDNF increased for RT (11.66 ± 5.20 vs. 19.60 ± 7.23; p = 0.001), but decreased for CTL (14.40 ± 4.99 vs. 10.84 ± 5.94; p = 0.001). Quality of life and mental health increased (p = 0.001) for RT, but did not change for CTL (p = 0.001). BDNF levels were associated with emotional dimensions of SF36, depressive symptoms, and handgrip (p = 0.001). CONCLUSIONS: RT was effective as a non-pharmacological tool to increased BDNF levels, quality of life, temper the redox balance and decrease depressive symptoms intensity in hemodialysis patients.

Influence of Angiotensin Converting Enzyme I/D Polymorphism on Hemodynamic and Antioxidant Response to Long-Term Intradialytic Resistance Training in Patients With Chronic Kidney Disease: A Randomized Controlled Trial.

ABSTRACT: Corrêa, HdL, Deus, LA, Neves, RVP, Reis, AL, de Freitas, GS, de Araújo, TB, da Silva Barbosa, JM, Prestes, J, Simões, HG, Amorim, CE, dos Santos, MAP, Haro, A, de Melo, GF, Gadelha, AB, Neto, LS, and Rosa, TdS. Influence of angiotensin converting enzyme I/D polymorphism on hemodynamic and antioxidant response to long-term intradialytic resistance training in patients with chronic kidney disease: a randomized controlled trial. J Strength Cond Res 35(10): 2902-2909, 2021-The aim of the study was to verify the influence of Angiotensin-converting enzyme (ACE) I/D genotype on blood pressure, muscle mass, and redox balance response to long-term resistance training (RT) in end-stage renal disease patients. Three hundred and twenty subjects were randomized into 4 groups: II + ID control (II + ID CTL, n = 80), II + ID RT (II + ID RT, n = 79), DD control (DD CTL n = 83), and DD RT (DD RT, n = 78). The RT lasted 24 weeks with a frequency of 3 times per week, on alternative days. Each section consisted of 3 sets of 8-12 repetitions in 11 exercises, with training loads at 6 point (somewhat hard) to 8 point (hard) based on OMNI-RES scale and was prescribed during dialysis (intradialytic). Statistical significance was accepted with p < 0.05. The most relevant benefits in blood pressure were found for DD homozygotes (p < 0.0001), whereas allele I carriers displayed a higher increase in muscle mass (p < 0.0001). Hemodialysis clinics that already use RT for their patients could include the genotyping of ACE to identify the predisposal of the patients to respond to RT and to counteract kidney disease-related comorbidities.

Efeitos do método pilates sobre a capacidade funcional, fatores antropométricos, marcadores inflamatórios e qualidade de vida em idosas sedentárias / Effects of the pilates method on functional capacity, anthropometric factors, inflammatory markers and quality of life in sedentary elderly women

O objetivo do presente estudo foi investigar os efeitos de exercícios físicos baseados no método Pilates solo sobre a capacidade funcional, fatores antropométricos, níveis de marcadores inflamatórios circulantes e a qualidade de vida em idosas sedentárias. Trata­se de um delineamento quase experimental com pré e pós teste. A amostra foi constituída por 33 mulheres idosas com idade igual ou superior a 60 anos. Para avaliar a capacidade funcional (CF) foram utilizados os testes de velocidade de caminhada (VC) e de força de preensão manual (FPM). Para avaliar a presença de marcadores inflamatórios foram realizados exames laboratoriais a fim de quantificar os níveis séricos de proteína C reativa ultrassensível (PCR-us) e fibrinogênio. E para avaliar a qualidade de vida (QV) foi utilizado o questionário SF ­ 36. Na análise estatística utilizou-se o teste de normalidade Shapiro Wilk. Para os dados paramétricos teste t pareado e ANOVA one Way e, para os dados não paramétricos, o teste Wilcoxon e Kruskal-Wallis. O teste Qui-Quadrado foi utilizado para analises de associações. Os dados foram analisados pelo no programa SPSS-IBM, versão 22.0 devidamente registrado. O nível de significância adotado foi de p≤0,05. O grupo Pilates não apresentou alterações estatisticamente significativas em relação à CF (p>0,05), porém as demais variáveis apresentaram diferença significativa. Para variáveis antropométricas, PCR e fibrinogênio (p < 0,05); e QV, dois domínios apresentaram alterações significativas: limitações por aspectos físicos (p=0,045) e dor (p=0,011). Conclui-se que a prática do método Pilates solo promoveu redução significativa sobre a composição corporal, sobre os níveis séricos de marcadores inflamatórios, sobre a qualidade de vida e manutenção da capacidade funcional de idosas sedentárias. (AU)

The aim of the present study was investigate the effects of exercises based on the Pilates method on functional capacity, anthropometric factors, levels of circulating inflammatory markers and quality of life in sedentary elderly women. It is an almost experimental design with pre and post-test. The sample considered of 33 elderly individuals, aged 60 years and female. In order to evaluate the functional capacity (FC), the tests of walking speed (WS) and manual grip strength (MGS) were used; to evaluate the presence of inflammatory markers, laboratory tests were performed to quantify the serum levels of C-reactive protein and fibrinogen, and the SF-36 questionnaire was used to evaluate the quality of life. For statistical analysis, Shapiro Wilk normality test was used. For parametric data, paired t- test and one-way ANOVA were used, and for nonparametric data, the Wilcoxon and Kruskal -Wallis test. Chi-square test was used for association analysis. All data were analyzed by SPSS-IBM, version 22.0 duly registered and the significance level of p ≤0.05 was stipulated. The Pilates group did not present significant alterations in relation to CF (p> 0.05), but the other variables presented. Anthropometric variables (total body mass, BMI, waist and hip circumference), C-reactive protein and fibrinogen (p< 0,05); and in relation to QV, two domains presented significant changes: limitations by physical aspects (p = 0.045) and pain (p = 0.011). It was concluded that the Pilates solo practice promoted a significant reduction in body composition, serum levels of inflammatory markers, quality of life and maintenance of functional capacity

Improving the prognosis of renal patients: The effects of blood flow-restricted resistance training on redox balance and cardiac autonomic function.

NEW FINDINGS: What is the central question of this study? Can resistance training with and without blood flow restriction improve redox balance and positively impact the autonomic cardiac modulation in chronic kidney disease patients? What is the main finding and its importance? Resistance training with and without blood flow restriction improved antioxidant defence (paraoxonase 1), decreased the pro-oxidative myeloperoxidase, improved cardiac autonomic function and slowed the decrease in renal function. We draw attention to the important clinical implications for the management of redox balance and autonomic cardiac function in chronic kidney disease patients. ABSTRACT: Patients with chronic kidney disease (CKD) are prone to cardiovascular diseases secondary to abnormalities in both autonomic cardiac function and redox balance [myeloperoxidase (MPO) to paraoxonase 1 (PON1) ratio]. Although aerobic training improves both autonomic balance and redox balance in patients with CKD, the cardioprotective effects of resistance training (RT), with and without blood flow restriction (BFR), remain unknown. We aimed to compare the effects of RT and RT+BFR on antioxidant defence (PON1), pro-oxidative status (MPO), cardiac autonomic function (quantified by heart rate variability analysis) and renal function. Conservative CKD (stages 1 to 5 who do not need hemodialysis) patients (n = 105, 33 female) of both sexes were randomized into three groups: control (CTL; 57.6 ± 5.2 years; body mass index, 33.23 ± 1.62 kg/m2 ), RT (58.09 ± 6.26 years; body mass index 33.63 ± 2.05 kg/m2 ) and RT+BFR (58.06 ± 6.47 years; body mass index, 33.32 ± 1.87 kg/m2 ). Patients completed 6 months of RT or RT+BFR on three non-consecutive days per week under the supervision of strength and conditioning professionals. Training loads were adjusted every 2 months. Heart rate variability was recorded with a Polar-RS800 and data were analysed for time and frequency domains using Kubios software. The redox balance markers were PON1 and MPO, which were analysed in plasma samples. Renal function was estimated as estimated glomerular filtration rate. The RT and RT+BFR decreased pro-oxidative MPO (RT, ∼34 ng/ml and RT+BFR, ∼27 ng/ml), improved both antioxidant defence (PON1: RT, ∼23 U/L and RT+BFR, ∼31 U/L) and cardiac autonomic function (R-R interval: RT, ∼120.4 ms and RT+BFR, ∼117.7 ms), and slowed the deterioration of renal function (P < 0.0001). Redox balance markers were inversely correlated with heart rate variability time-domain indices. Our data indicated that both training models were effective as non-pharmacological tools to increase the antioxidant defences, decrease oxidative stress and improve the cardiac autonomic function of CKD patients.

Effects of pre-dialysis resistance training on sarcopenia, inflammatory profile, and anemia biomarkers in older community-dwelling patients with chronic kidney disease: a randomized controlled trial.

BACKGROUND: Sarcopenia and chronic kidney disease (CKD) have been associated with negative outcomes in older people, including inflammatory profile and anemia biomarkers. AIMS: To investigate the effects of pre-dialysis resistance training (RT) on sarcopenia, inflammatory profile, and anemia biomarkers in older patients with CKD. METHODS: A total of 107 patients with CKD (65.4 ± 3.7 years) were randomly allocated into four groups: sarcopenic RT (n = 37), non-sarcopenic RT (n = 20), sarcopenic control (n = 28), and non-sarcopenic control (n = 22). DXA and handgrip strength were used to classify sarcopenia according to EWGSOP-2. Treatment groups underwent a 24-week intervention with RT before each dialysis session, three times per week. Blood sample analysis for ferritin, hepcidin, iron availability, and inflammatory profile (TNFα, IL-6, and IL-10) was conducted. All-cause mortality was recorded over 5 years. RESULTS: Sarcopenic RT group increased iron availability after the intervention, while their counterparts decreased. Ferritin and hepcidin significantly decreased in sarcopenic RT group. RT elicited a reduction in both TNFα and IL-6, while increasing IL-10 in both intervention groups. The rate of sarcopenic subjects substantially decreased after the intervention period (from 37 to 17 in the RT group; p = 0.01). The proportion of deaths was higher (P = 0.033) for sarcopenic subjects (Controls 35.7% vs RT 29.7%) when compared to non-sarcopenic subjects (Controls 18% vs RT 10%). The proportion of deaths decreased according to the randomization group (X2 = 8.704; P < 0.1). CONCLUSIONS: The 24-week RT intervention elicited a better sarcopenia status, better inflammatory profile, and improved anemia biomarkers. Sarcopenia was associated with higher mortality rate in older patients with CKD.

Avaliação da Autoeficácia e da Memória em Idosos: Uma Análise Exploratória / Self-Efficacy and Memory Assessment in Elderly: An Exploratory Analysis

Resumo Trata-se de um estudo exploratório, transversal e quantitativo, cujo objetivo foi verificar as alterações da memória e da autoeficácia em 110 idosos, com média de 70,5 anos. Foram utilizados um questionário sociodemográfico, um teste de percepção subjetiva de memória, o questionário de memória Prospectiva e Retrospectiva e a Lista de Aprendizagem Auditivo-Verbal de Rey. Os idosos foram avaliados em um único momento, individualmente, por cerca de 60 minutos. Os resultados do teste de memória apresentaram-se dentro dos padrões esperados para a idade e a escolaridade, com leve desempenho inferior na memória de trabalho e percepção negativa da autoeficácia da memória (82,70%). Tal desempenho foi associado às queixas subjetivas de memória (99,10%), o que pode ser explicado por paradigmas socioculturais atrelados negativamente ao processo de envelhecer.

Abstract It is an exploratory, cross-sectional and quantitative study whose objective was to verify memory and self-efficacy alterations in 110 older adults, with a mean of 70.50 years. We used a sociodemographic questionnaire, a subjective memory perception test, the Prospective and Retrospective Memory Questionnaire, and The Rey Auditory-Verbal Learning Test. The seniors were evaluated in a single moment, individually, for about 60 minutes. The results of the memory test were within the expected standards for age and schooling, with a slightly inferior performance in working memory and negative perception of memory self-efficacy (82.70%). Such performance was associated with subjective memory complaints (99.10%), which can be explained by socio-cultural paradigms negatively linked to the aging process.

Obese elderly with diabetes experience more pain and reduced quality of life compared to obese elderly with hypertension.

BACKGROUND AND AIM: Growth of elderly population is a worldwide phenomenon that impacts public health. The objective of this study was to compare the pain levels, strength, and quality of life among elderly obese with diabetes or hypertension. MATERIALS AND METHODS: The study cohort comprised 52 obese elderly subjects with hypertension (n = 35) and diabetes (n = 17). The parameters measured were anthropometric features, handgrip strength, visual analog scale for pain, and quality of life using the World Health Organization questionnaire. RESULTS: The level of pain reported by obese hypertensive elderly subjects (5.3 ± 3.4) was lower than reported by obese diabetic elderly subjects (7.4 ± 2.4). Obese hypertensive elderly scored higher on quality of life (sensory functioning and past, present, and future [PPF] activities) than obese diabetic elderly. No differences were observed for the other parameters. Strength, pain, anthropometrics, and hemodynamics were not correlated to quality of life. CONCLUSIONS: Obese elderly diabetics exhibit worse pain scores, sensorial abilities, and PPF activities than obese hypertensive elderly individuals. RELEVANCE FOR PATIENTS: The difference in pain and quality of life aspects between obese elderly individuals with hypertension and diabetes should be accounted for in health-care programs designed for these individuals.

Resistance training improves sleep quality, redox balance and inflammatory profile in maintenance hemodialysis patients: a randomized controlled trial.

Patients in maintenance hemodialisys (HD) present sleep disorders, increased inflammation, unbalanced redox profiles, and elevated biomarkers representing endothelial dysfunction. Resistance training (RT) has shown to mitigate the loss of muscle mass, strength, improve inflammatory profiles, and endothelial function while decreasing oxidative stress for those in HD. However, the relation between those factors and sleep quality are inadequately described. The aim of this study was to verify the effects of 3 months of RT on sleep quality, redox balance, nitric oxide (NO) bioavailability, inflammation profile, and asymmetric dimethylarginine (ADMA) in patients undergoing HD. Our primary goal was to describe the role of RT on sleep quality. Our secondary goal was to evaluate the effect of RT on NO, metabolism markers, and inflammatory and redox profiles as potential mechanisms to explain RT-induced sleep quality changes. Fifty-five men undergoing maintenance hemodialysis were randomized into either a control (CTL, n = 25) and RT group (RTG; n = 30). Participants in the RT group demonstrated an improvement in sleep pattern, redox, inflammatory profiles, and biomarkers of endothelial function (NO2- and ADMA). This group also increased muscle strength (total workload in RT exercises of upper and lower limbs). These findings support that RT may improve the clinical status of HD patients by improving their sleep quality, oxidative and inflammatory parameters.